Based on hourly temperature and precipitation grid data of CMA land data assimilation system (CLDAS), ground meteorological observation data at 119 weather stations of Inner Mongolia and the spatial distribution of irrigated crop fields, the key meteorological factors and climatic division indexes were determined by considering fully planting technology and agricultural climatic characteristics of sunflower following spring wheat harvest in agro-climatic ecological regions of Inner Mongolia. And taking suitable growth days and climate suitability in the whole growth period as zoning indicators, the refined climatic suitability division of sunflower following spring wheat harvest in Inner Mongolia was studied under the operation of ArcGIS. The results show that the heat shortage and drought in growing season mainly restricted the regular growth and yield formation of sunflower following spring wheat harvest in Inner Mongolia, and the whole region was divided into unsuitable zone, more suitable zone, suitable zone and the most suitable zone. The irrigation conditions in Hetao irrigation district, Tumochuan plain and West Liaohe plain were better, which were particularly suitable to the growth of sunflower following spring wheat harvest, so these regions were the most suitable districts of sunflower growing. Due to serious shortage of heat resource in most areas of middle and eastern Inner Mongolia and the deficit of precipitation in the north of mid-western Inner Mongolia after the transplanting, the sunflower following spring wheat harvest was quite immature, so these regions were unsuitable areas of sunflower growing. The climatic suitability division of sunflower following spring wheat harvest based on grid data of CLDAS was consistent with the division distribution based on meteorological data of weather stations in Inner Mongolia, but the details of CLDAS data division were more refined than that of stations data. Hetao irrigation district was the most suitable area of sunflower following spring wheat harvest in Inner Mongolia, which was accord with the current layout of sunflower following spring wheat harvest. Therefore, this division result could provide some references for the rational layout of sunflower following spring wheat harvest in Inner Mongolia under the background of climate change.